Dr Alan Brisdon.

Senior Lecturer
School of Chemistry
Tel.: 0161 306 4459
Related Web pages: http://fluorine.ch.man.ac.uk

Background:

High-oxidation-state fluorine chemistry; the fluorination of carbon-based systems; the application of fluorocarbons to co-ordination, fluoro-organometallic chemistry and ligand design.

Research Interests:

Applying the new, commercially available HFC (hydrofluorocarbon) products, developed as CFC (chlorofluorocarbon) replacements to the synthesis of novel fluorine-containing inorganic and organometallic compounds. Developing new metal-based fluorination methods and fluoroorgano-group transfer reagents.

Recent work has shown that the new HFCs, and related materials, can be used for introducing fluorine-containing groups into a wide variety of molecules[1]. For example perfluorovinyl lithium derived from the CFC-replacement HFC-134a (CF3CH2F) can be used to generate a number of perfluorovinyl-containing compounds[2], ligands [3] and complexes [4,5]. This work has resulted in the first structural characterisation of a number of fluorvinyl-based systems. Applications of these materials has, so far been concentrated in two areas. Firstly, the synthesis of simple ligand systems, which has provided air- and moisture-stable ligands exhibiting phosphite-like electronic properties. Secondly, we have started to investigate the use of metal-based complexes of these fluoroorganic groups as transfer reagents. Work in these areas is supported, in part, by Johnson Matthey, ICI Klea, the Royal Society and the EPSRC.

References:

Perfluorovinyl-metal derivatives: a new one-pot synthesis. K. K. Banger, A. K. Brisdon, A. Gupta, Chem. Commun., 1997, 139-140.
Hydrofluorocarbon 245fa: a versatile new synthon in alkyne chemistry.A. K. Brisdon, I. R. Crossley, Chem. Commun., 2002, 2420-2421.
Ringing the changes: A remarkable carbene-free synthesis of difluorocyclopropenes.A. K. Brisdon, I. R. Crossley, K. R. Flower, R. G. Pritchard, J. E. Warren, Angew. Chem.,Int. Ed., 2003, 42, 2399-2401.
Preparation and Functionalization of a Range of Main-Group Trifluoropropynyl Organometallic Compounds: The Application of Metalloid-Directed Carbolithiation to the Selective Synthesis of Novel Fluorocarbon Fragments, A. K. Brisdon, I. R. Crossley, R. G. Pritchard, G. Sadiq, J. E. Warren, Organometallics, 2003, 22, 5534-5542.
Immiscible electrolyte systems based on asymmetric hydrophobic room temperature ionic liquids, A. D. Ballantyne, A. K. Brisdon, R. A. W. Dryfe, Chem. Commun., 2008, 4980-4982.
A Generic Route to Fluoroalkyl-containing Phosphanes, A. K. Brisdon, C. J. Herbert, Chem. Commun., 2009, 6658-6660.
Fluoroalkenyl, Fluoroalkynyl and Fluoroalkyl Phosphines, K. K. Banger, A. K. Brisdon, C. J. Herbert, H. Ali Ghaba, I. S. Tidmarsh, J. Fluorine Chem., 2009, 130, 1117-1129.

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Tag Cloud
Fluorine@Manchester
HFC-134a cylinder, a solvent for enzyme reactions

HFCs for biological transformations
Jason Micklefield's group pioneered the use of HFCs as solvents for enzymatic reactions.

Fluorine in Society
An LCD display

Modern Display Devices
Flat screen TVs & computer LCD displays work efficiently because they contain fluorine-containing compounds.